Refrigerated centrifuges are indispensable in modern laboratories, especially when working with temperature-sensitive samples. Whether you need a high-speed refrigerated centrifuge for molecular biology, a compact refrigerated centrifuge for clinical diagnostics, or a benchtop refrigerated centrifuge for routine research, choosing the right equipment ensures sample integrity and reliable results.
If you’re exploring options beyond the models listed here, browse our full range of centrifuges for every laboratory need.
This guide covers the best refrigerated centrifuges for laboratories in 2025, compares leading models, and offers a practical refrigerated centrifuge buying guide for research and clinical applications. For an in-depth overview of centrifuge types, features, and buying considerations, see our comprehensive Centrifuge Buying Guide. If you’re deciding between a portable or benchtop model, check out our detailed Portable vs Benchtop Centrifuges comparison.
Quick Comparison Table: Top Refrigerated Centrifuges for Laboratories
| Model | Max Speed / RCF | Capacity | Temperature Range | Best For |
|---|---|---|---|---|
| Eppendorf Centrifuge 5427 R | 16,220 rpm / 25,000×g | 48 × 1.5/2.0 mL | −11°C to 40°C | Molecular biology, research |
| Thermo Scientific Sorvall X Pro | 15,000 rpm / 26,000×g | Up to 4 × 1000 mL | −10°C to 40°C | High-throughput, clinical use |
| Beckman Coulter Avanti JXN-30 | 30,000 rpm / 100,000×g | Up to 6 × 1000 mL | −20°C to 40°C | Large-scale, industrial labs |
| Hettich Rotina 420 R | 15,000 rpm / 24,400×g | Up to 4 × 250 mL | −20°C to 40°C | Clinical, routine lab work |
Best Refrigerated Centrifuges for Research & Clinical Use
Eppendorf Centrifuge 5427 R
A standout among Eppendorf refrigerated centrifuges, the 5427 R is a compact refrigerated centrifuge ideal for molecular biology labs and small-volume clinical applications. This microcentrifuge with a cooling system delivers precise temperature control, making it one of the best centrifuges for research applications needing sensitive sample handling.
Key Features:
- Max Speed: 16,220 rpm (25,000×g)
- Capacity: 48 × 1.5/2.0 mL tubes
- Temperature Range: −11°C to 40°C
- Silent centrifuge operation (<45 dB)
- Digital display and ergonomic controls
- Automatic rotor recognition
Best for: Small-volume research, molecular biology, diagnostic testing labs
Efficient sample prep is essential—discover our range of homogenizers designed for labs working with complex biological or chemical samples.
Thermo Scientific Sorvall X Pro
As a high-capacity refrigerated centrifuge, the Sorvall X Pro is a top choice for laboratories requiring versatility and throughput. This Thermo Fisher centrifuge supports a wide range of rotor types, making it suitable as both a clinical centrifuge machine and research centrifuge equipment.
Key Features:
- Max Speed: 15,000 rpm (26,000×g)
- Capacity: Up to 4 × 1000 mL
- Temperature Range: −10°C to 40°C
- ClickSeal® biocontainment lids
- Variable speed centrifuge with cooling
- Touchscreen digital display
Best for: Clinical labs, bioprocessing, high-throughput research
Proper storage is crucial for sensitive materials—explore our selection of laboratory refrigerators and laboratory freezers for reliable sample preservation before and after centrifugation.
Beckman Coulter Avanti JXN-30
For labs needing a high-speed refrigerated centrifuge with maximum capacity, the Beckman Coulter centrifuge Avanti JXN-30 is a premier option. This model is a favorite for industrial, biopharmaceutical, and large academic labs.
Key Features:
- Max Speed: 30,000 rpm (100,000×g)
- Capacity: Up to 6 × 1000 mL
- Temperature Range: −20°C to 40°C
- Remote monitoring and digital programming
- Robust build for continuous operation
Best for: Large-scale research, biopharma, industrial and quality control labs
For samples requiring ultra-low temperatures, our laboratory freezers provide secure, dependable storage options.
Hettich Rotina 420 R
The Hettich centrifuge machines are known for reliability and user-friendliness. The Rotina 420 R is a versatile benchtop refrigerated centrifuge suitable for both clinical and routine research tasks.
Key Features:
- Max Speed: 15,000 rpm (24,400×g)
- Capacity: Up to 4 × 250 mL
- Temperature Range: −20°C to 40°C
- Broad rotor compatibility
- Simple control panel with digital display
Best for: Clinical use, educational labs, routine sample processing
For more on essential clinical lab equipment, see our guide to the Best Clinical Lab Microscopes.
Key Features to Consider in a Refrigerated Lab Centrifuge
When selecting the best refrigerated centrifuge for clinical labs or research, consider these essential features:
- Speed & RCF: Choose a high-speed refrigerated centrifuge for applications needing rapid separation.
- Capacity: Ensure your clinical centrifuge machine can handle your typical sample volume.
- Rotor Types: Fixed-angle and swing-out rotors support different sample formats.
- Temperature Control: Look for a centrifuge machine with temperature control and a wide temperature range.
- Digital Display & Programming: A centrifuge with a digital display simplifies operation and reduces errors.
- Noise Level: Silent centrifuge operation is vital in compact or shared spaces.
- Maintenance & Calibration: Easy centrifuge maintenance and calibration extend equipment life.
- Safety Features: Imbalance detection, lid locks, and biocontainment are crucial for lab safety.
Accurate sample measurement is essential before centrifugation. Explore our collection of precision laboratory balances to ensure reliable results. Learn more in our Analytical vs Precision Balances guide, or compare Ohaus vs Mettler Toledo Balances.
For comprehensive temperature management, consider pairing your centrifuge with specialized lab cold storage solutions to keep samples safe before and after processing.
Refrigerated Centrifuge Buying Guide: How to Choose the Right Model
Every lab has unique needs. Here’s how to choose a refrigerated centrifuge that fits your workflow:
1. Define Your Application
- For molecular biology and genomics, select a microcentrifuge with a cooling system and precise speed control.
- For diagnostic testing labs, prioritize a clinical centrifuge machine with high throughput and easy rotor changes.
- For general research, a versatile benchtop refrigerated centrifuge with variable speed and rotor types is ideal.
If you’re outfitting a new lab, don’t miss our guide on Choosing the Right Lab Equipment for Startups.
2. Assess Capacity and Space
- Compact refrigerated centrifuges are perfect for smaller labs.
- High-capacity refrigerated centrifuges suit industrial and large-scale research facilities.
3. Consider Technical Requirements
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Check the centrifuge temperature range, power requirements, and compatibility with your sample tubes.
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Look for a variable-speed centrifuge with cooling for flexible protocols.
4. Ask the Right Questions
- What is the maintenance and calibration history?
- Are all required rotors and adapters included?
- Is there a warranty or technical support?
- Does the unit feature a digital display and easy-to-use controls?
When purchasing any lab equipment, also consider upstream and downstream needs—see our lab equipment collection for a full range of solutions.
5. Avoid Common Mistakes
- Don’t underestimate future capacity needs.
- Ensure rotor compatibility for your labware.
- Never overlook the importance of quiet, reliable operation.
Explore our Analytical Balances Guide for tips on precise weighing, or discover the Best PCR Machines for Clinical & Diagnostic Labs.
Final Thoughts
Selecting the best refrigerated centrifuge for your laboratory is a critical investment that impacts your workflow, sample quality, and research outcomes. Whether you need a high-capacity clinical centrifuge machine or a compact refrigerated lab centrifuge for research, consider your current and future needs, compare top brands like Eppendorf, Thermo Fisher, Beckman Coulter, Ohaus, and Hettich, and use this guide to make an informed decision.
For more information, consult with suppliers or explore detailed product specs to find the perfect centrifuge for your lab. Accurate sample measurement is foundational—see our balances collection for reliable options. For comprehensive cold storage, visit our lab cold storage, laboratory refrigerators, and laboratory freezers collections.
If you’re interested in other essential lab equipment, check out our expert guides on analytical balances, homogenizers, and PCR machines.
Related Guides & Comparisons:
- Centrifuge Buying Guide
- Portable vs Benchtop Centrifuges
- Best Clinical Lab Microscopes
- Best Homogenizers for Food Science & Biotech Labs
- Analytical Balances Guide
- Ohaus vs Mettler Toledo Balances
- Analytical vs Precision Balances
- Best PCR Machines for Clinical & Diagnostic Labs
- Choosing the Right Lab Equipment for Startups